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If a lack of vitamin B12 prevents the brain from making these chemicals, you may experience common depressive symptoms, like: Anxiety Irritability Sadness Restlessness Additionally, a B12 deficiency can: Lead to increased amounts of the amino acid homocysteine, which can make depression worse [9]

Contact your doctor as soon as possible if you experience any new or changing symptoms after using vitamin B12 injections or supplements

Johns Hopkins

Maintenance protocols typically use lower doses than initial loading phases